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The phosphorylated HER3 delivers docking web sites for p85 subunit of PI3K. The completely activated PI3K elaborate is created by binding of p110 subunit of PI3K to p85 which will be able to generate PIP3 by using phosphorylating the PIP2. AKT binds to PIP3 and is phosphorylated by PDK1 and mTORC2. Phosphorylation of AKT at the two threonine and se